Evaluation of Measles Vaccine Virus as a Vector to Deliver Respiratory Syncytial Virus Fusion Protein or Epstein-Barr Virus Glycoprotein gp350

Mok, Hoyin; Cheng, Xing; Xu, Qi; Zengel, James R; Parhy, Bandita; Zhao, Jackie; Wang, C. Kathy; Jin, Hong

In this study, we explored the use of the EZ vaccine strain to deliver viral antigens for prevention of RSV and EBV associated diseases. RSV causes severe lower respiratory tract illness in infants and the elderly. Bronchiolitis from RSV infection in infants is associated with recurrent wheezing and asthma in childhood [24] . No vaccine is available to prevent morbidity and mortality from RSV infection. The surface fusion (F) protein of RSV is a major antigenic protein that induces neutralizing antibodies, CD8 + cytotoxic T lymphocytes, and protection against subsequent RSV challenge in mice or cotton rats [25] . High levels of F neutralizing antibodies are sufficient to protect the lower respiratory tract infection [26] and have been used for prophylactic purpose in infants.