Author: Sabath, Niv; Wagner, Andreas; Karlin, David
Title: Evolution of Viral Proteins Originated De Novo by Overprinting Document date: 2012_7_19
ID: 629fwmgk_2
Snippet: Most studies in this area have focused on eukaryotes, which are not necessarily the best organisms to study de novo genes. First, the incidence of de novo gene origination may be relatively low in eukaryotes, ranging from 2 to 12% of all new gene origination events according to recent estimates Toll-Riera et al. 2009a; Ekman and Elofsson 2010) . Second, direct experimental evidence for the expression of the proteins encoded by candidate de novo g.....
Document: Most studies in this area have focused on eukaryotes, which are not necessarily the best organisms to study de novo genes. First, the incidence of de novo gene origination may be relatively low in eukaryotes, ranging from 2 to 12% of all new gene origination events according to recent estimates Toll-Riera et al. 2009a; Ekman and Elofsson 2010) . Second, direct experimental evidence for the expression of the proteins encoded by candidate de novo genes is not always available in eukaryotes-some might be artifacts of genome annotation . Third, most eukaryotic candidate genes are structurally and functionally poorly characterized. Finally, current protocols to identify genes created de novo from noncoding sequences in eukaryotic genomes focus on genes with similarity to genes already annotated in the genome sequence, whereas some de novo genes may not be currently annotated, even as hypothetical, which would preclude their discovery (Guerzoni and McLysaght 2011) .
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