Author: Wu, Joseph T.; Peak, Corey M.; Leung, Gabriel M.; Lipsitch, Marc
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study Document date: 2016_11_10
ID: 02pjdufw_36
Snippet: Rollout of fractionated dosing should perhaps be preceded or accompanied by noninferiority studies of the intended vaccine's immunogenicity at fractional doses in the intended populations. Ongoing programs should be monitored by observational studies of safety, immunogenicity and, if possible, effectiveness 18 to assure that the assumptions underlying the rationale for such programs continue to be met. However, it is worth noting that if fulldose.....
Document: Rollout of fractionated dosing should perhaps be preceded or accompanied by noninferiority studies of the intended vaccine's immunogenicity at fractional doses in the intended populations. Ongoing programs should be monitored by observational studies of safety, immunogenicity and, if possible, effectiveness 18 to assure that the assumptions underlying the rationale for such programs continue to be met. However, it is worth noting that if fulldose vaccine efficacy is indeed 100% or nearly so as currently believed, estimating the relative efficacy of fractional vs. standard doses in a comparative study would be challenging or impossible, as there might be few or no cases accrued in the standard-dose arm.
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