Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma Document date: 2019_6_4
ID: 6j3k3viu_26
Snippet: ORM1-like-3 (ORMDL3) is localized to the endoplasmic reticulum and regulates downstream pathways including sphingolipids, the activating transcription factor 6α pathway of the unfolded protein response, metalloproteases, remodeling genes and chemokines. 39 In mouse models, ORMDL3 plays an important role in airway remodeling, including increased airway smooth muscle, sub-epithelial fibrosis and mucus. 45 To date, few human studies have reported w.....
Document: ORM1-like-3 (ORMDL3) is localized to the endoplasmic reticulum and regulates downstream pathways including sphingolipids, the activating transcription factor 6α pathway of the unfolded protein response, metalloproteases, remodeling genes and chemokines. 39 In mouse models, ORMDL3 plays an important role in airway remodeling, including increased airway smooth muscle, sub-epithelial fibrosis and mucus. 45 To date, few human studies have reported whether ORMDL3 genetic variants are associated with features of airway remodeling or decline in lung function in asthma.
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