Selected article for: "airway lung function decline and lung function"
Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
  • Document date: 2019_6_4
    • ID: 6j3k3viu_26
    Snippet: ORM1-like-3 (ORMDL3) is localized to the endoplasmic reticulum and regulates downstream pathways including sphingolipids, the activating transcription factor 6α pathway of the unfolded protein response, metalloproteases, remodeling genes and chemokines. 39 In mouse models, ORMDL3 plays an important role in airway remodeling, including increased airway smooth muscle, sub-epithelial fibrosis and mucus. 45 To date, few human studies have reported w.....
    Document: ORM1-like-3 (ORMDL3) is localized to the endoplasmic reticulum and regulates downstream pathways including sphingolipids, the activating transcription factor 6α pathway of the unfolded protein response, metalloproteases, remodeling genes and chemokines. 39 In mouse models, ORMDL3 plays an important role in airway remodeling, including increased airway smooth muscle, sub-epithelial fibrosis and mucus. 45 To date, few human studies have reported whether ORMDL3 genetic variants are associated with features of airway remodeling or decline in lung function in asthma.

    Search related documents:
    Co phrase search for related documents
    • activate transcription factor and protein response: 1
    • airway feature and asthma lung function decline: 1
    • airway feature and lung function: 1
    • airway feature and lung function decline: 1
    • airway feature and mouse model: 1
    • asthma lung function decline and genetic variant: 1
    • asthma lung function decline and important role: 1
    • asthma lung function decline and increase airway smooth muscle: 1
    • asthma lung function decline and lung function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
    • asthma lung function decline and lung function decline: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
    • asthma lung function decline and mouse model: 1
    • asthma lung function decline remodeling and genetic variant: 1
    • asthma lung function decline remodeling and important role: 1
    • asthma lung function decline remodeling and increase airway smooth muscle: 1
    • asthma lung function decline remodeling and lung function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • asthma lung function decline remodeling and lung function decline: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • asthma lung function decline remodeling and mouse model: 1
    • downstream pathway and endoplasmic reticulum: 1, 2, 3, 4, 5
    • downstream pathway and human study: 1, 2