Author: Monika Litvinukova; Carlos Talavera-Lopez; Henrike Maatz; Daniel Reichart; Catherine L. Worth; Eric L. Lindberg; Masatoshi Kanda; Krzysztof Polanski; Eirini S. Fasouli; Sara Samari; Kenny Roberts; Elizabeth Tuck; Matthias Heinig; Daniel DeLaughter; Barbara McDonough; Hiroko Wakimoto; Joshua M. Gorham; Emily Nadelmann; Krishnaa T. Mahbubani; Kourosh Saeb-Parsy; Giannino Patone; Joseph J Boyle; Hongbo Zhang; Hao Zhang; Anissa Viveiros; Gavin Oudit; Omer Bayraktar; J. G. Seidman; Christine Seidman; Michela Noseda; Norbert Hubner; Sarah A. Teichmann
Title: Cells and gene expression programs in the adult human heart Document date: 2020_4_5
ID: 1ilforzm_37
Snippet: In skeletal muscle, predicted cell-cell interactions between PRG4+ fibroblasts and skeletal muscle myocytes involved COL1A2 , COL6A2 and a10b1 integrins ( Figure 5D ). Skeletal muscle fibroblasts and monocytes appear to interact via the CXCR4_CXCL12 chemokine, while cardiomyocytes have a distinct interaction with macrophages as described above in Figure 4D . Altogether, these results imply interactive mechanisms are driven by different transcript.....
Document: In skeletal muscle, predicted cell-cell interactions between PRG4+ fibroblasts and skeletal muscle myocytes involved COL1A2 , COL6A2 and a10b1 integrins ( Figure 5D ). Skeletal muscle fibroblasts and monocytes appear to interact via the CXCR4_CXCL12 chemokine, while cardiomyocytes have a distinct interaction with macrophages as described above in Figure 4D . Altogether, these results imply interactive mechanisms are driven by different transcriptional circuits in heart and skeletal muscle. The circuit between CXCR4_CXCL12, which has been described to promote repair after myocardial infarction 81 appears to be primed by myeloid populations that initiate fibrotic repair. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.03.024075 doi: bioRxiv preprint provide detailed insights across the repertoire of cardiac cells, including CM (excluded by scRNA-Seq) as well as EC (underrepresented in cardiac snRNA-Seq) ( Figure 1C ). We quantify the cellular composition between cardiac chambers and across donors, highlighting chamber-specific features and differences between male and female donors.
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