Author: Smith, Ryan Kenneth; Gerrits, Peter M.
Title: A Rare Case of Autoimmune Polyglandular Syndrome Type 2 in a Child With Persistent Fatigue Document date: 2019_5_1
ID: 6hxn482r_11
Snippet: The Endocrine Society recently published a clinical practice guideline that details recommendations for both diagnosis and treatment of primary adrenal insufficiency. 2 The cosyntropin stimulation test is recommended for establishing the diagnosis of adrenal insufficiency, together with measurement of plasma ACTH, renin, and aldosterone levels. 2 Treatment includes replacement of both glucocorticoid and mineralocorticoid hormones with hydrocortis.....
Document: The Endocrine Society recently published a clinical practice guideline that details recommendations for both diagnosis and treatment of primary adrenal insufficiency. 2 The cosyntropin stimulation test is recommended for establishing the diagnosis of adrenal insufficiency, together with measurement of plasma ACTH, renin, and aldosterone levels. 2 Treatment includes replacement of both glucocorticoid and mineralocorticoid hormones with hydrocortisone and fludrocortisone, respectively. 2 Numerous are the etiologies of primary adrenal insufficiency, including autoimmune (isolated or part of APS), adrenal injury, infectious, congenital adrenal hyperplasia, drug-induced, or metabolic disorders such as mitochondrial diseases or adrenoleukodystrophy. 2 Thus, effective treatment must be directed toward the underlying cause.
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