A review of vaccine development and research for industry animals in Korea

Lee, Nak-Hyung; Lee, Jung-Ah; Park, Seung-Yong; Song, Chang-Seon; Choi, In-Soo; Lee, Joong-Bok

For instance, rabies vaccine is a prototype of vector vaccine currently in use in several countries. An oral cowpox-rabies bait vaccine that contains G glycoprotein, a protective antigen of rabies virus, is able to prevent rabies of wild carnivores, such as foxes, raccoon, and coyotes. A recombinant vaccinia virus containing the gene encoding the glycoprotein of rabies virus was able to administered many types of wildlife in order to protect against rabies (in use in EU, North America and Korea) . Interestingly, such vaccine can be used as a DIVA vaccine since fowls vaccinated with this virus do not form antibodies against matrix protein or nucleoprotein. For examples, the haemagglutinin (HA) gene of influenza virus is incorporated within a gene-deleted vaccine strain of fowl pox. This provokes immune responses against HA protein in vaccinated chickens, resulted in protection against both diseases. This vaccine has been shown to be effective in the field against morbidity and shedding of the influenza virus once it was used as a primary vaccine. Administration of replication-incompetent glycoprotein B-expressing adenovirus induced Th1-based humoral and cellular immune response and provided effective protection against virulent pseudorabies challenge [20] .