Author: Lee, Nak-Hyung; Lee, Jung-Ah; Park, Seung-Yong; Song, Chang-Seon; Choi, In-Soo; Lee, Joong-Bok
Title: A review of vaccine development and research for industry animals in Korea Document date: 2012_7_31
ID: 1c1jd9oz_22
Snippet: For examples, the immunogenicity of VLP vaccine expressing HA and M1 proteins of H9N2 AIV after immunization for chickens was measured by ELISA using the expressed nucleocapsid antigen. Since the protein was not carried on the surface of the VLP vaccine, this showed the differentiation of AIV-infected chickens from vaccinated ones [28] . Nonstructural protein 1 (NS1) of West Nile virus (WNV) can be the most reliable indicator of past infection in.....
Document: For examples, the immunogenicity of VLP vaccine expressing HA and M1 proteins of H9N2 AIV after immunization for chickens was measured by ELISA using the expressed nucleocapsid antigen. Since the protein was not carried on the surface of the VLP vaccine, this showed the differentiation of AIV-infected chickens from vaccinated ones [28] . Nonstructural protein 1 (NS1) of West Nile virus (WNV) can be the most reliable indicator of past infection in animals. The NS1competitive ELISA using a monoclonal antibody against the expressed NS1 demonstrated the capability of differentiating wild type virus infected animals from the animals vaccinated with killed WNV vaccine. This would be considered as a potential DIVA means capable of monitoring WNV transmission [29] . The VLP vaccine of highly pathogenic avian influenza (HPAI) was recently constructed and immunized into specific pathogen free chickens. Such vaccination induced high levels of haemagglutination and neuraminidase inhibition in the vaccinated chickens as compared to control group. Furthermore, it was possible to differentiate VLP-vaccinated chickens from the infected ones using a commercial ELISA kit [30] .
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