A review of vaccine development and research for industry animals in Korea

Lee, Nak-Hyung; Lee, Jung-Ah; Park, Seung-Yong; Song, Chang-Seon; Choi, In-Soo; Lee, Joong-Bok

For examples, the VP1 gene of FMDV carries critical epitopes for inducing immune response to neutralize FMDV. DNA vaccine containing the VP1 epitopes of FMDV has the ability to elicit both FMDV specific T cell proliferation and neutralizing antibody against FMD in swine [38] . DNA vaccine containing VP243 of infectious bursal disease virus (IBDV), an acute and highly contagious diseases in chickens, has been shown to exhibit higher survival rate and low bursal atrophy as compared with the non-immunized groups after challenge. Immunity derived from the DNA vaccination seems to contribute to a high level of protective immunity and the overall protection of chickens against IBDV [39] . A plasmid DNA containing the gD gene of Aujeszky's disease virus (ADV) elicited serum neutralizing antibody at 4 weeks after immunization, indicating that it may be a DNA vaccine candidate against ADV [40] . Administration of DNA vaccine containing the N3 gene of severe acute respiratory syndrome (SARS), a life-threatening and highly emerging disease, elicited a significant level of antibody responses in the vaccinated mice, which can be a potential DNA vaccine candidate against SARS [41] .