2015 ACVIM Forum Research Abstract Program

In this study, serum ca 1 -PI concentrations were significantly lower in dogs with SIRS or sepsis than in healthy control dogs, and septic patients had lower serum ca 1 -PI concentrations on days 2 and 3 than dogs with non-infectious SIRS. These results would argue for a role of ca 1 -PI as a negative acute-phase protein in dogs, and may suggest that the proteinproteinase inhibitor balance is altered in dogs with systemic inflammation. Further studies to evaluate the role of ca 1 -PI in the acute-phase response as well as its utility as a biomarker for the diagnosis and differentiation of dogs with SIRS or sepsis are warranted. In dogs, ibuprofen intoxication is common, occurring through either administration by owners or dietary indiscretion. Intoxication can result in acute gastrointestinal signs and kidney injury. Historically, it has been treated with supportive care. No published studies have reported use of TPE to reduce serum ibuprofen concentrations. We hypothesized that TPE could be used as an adjunctive or alternative treatment for ibuprofen toxicity.