Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_790
Snippet: There was no systemic adverse effect on the dogs either during the treatment or during the following 7 days. Tulobuterol was rapidly absorbed after intravenous administration with a t max of 0.017 hour. Tulobuterol was well absorbed after transdermal administration with an absorption lag-time of about 4-8 hour. The C max of tulobuterol in dogs reached 2.09 ng/mL at 16.0 hours and reached 4.85 ng/mL at 13.6 hours after the transdermal administrati.....
Document: There was no systemic adverse effect on the dogs either during the treatment or during the following 7 days. Tulobuterol was rapidly absorbed after intravenous administration with a t max of 0.017 hour. Tulobuterol was well absorbed after transdermal administration with an absorption lag-time of about 4-8 hour. The C max of tulobuterol in dogs reached 2.09 ng/mL at 16.0 hours and reached 4.85 ng/mL at 13.6 hours after the transdermal administration of 0.2 and 0.4 mg/kg. Existing literature report that the effective blood level of tulobuterol in human medicine is 1-3 ng/mL. As evident from this study, the ideal blood drug concentration was reached by applying 0.2 mg/kg of the patch.
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