2015 ACVIM Forum Research Abstract Program

Treatment group 4 (n:8): 7.2% hypertonic saline (4 mL/kg) was given via IV and followed oral electrolyte solution (60 mL/ kg) was administrated. Intravenous solutions was given to all calves by infusion machine. The changes in clinic, hemodynamic, hematologic, blood gas, plasma volume, serum electrolyte and proteins were determined periodically during 24 hours following fluid administration to calves. Calves that received intravenous isotonic sodium bicarbonate, hypertonic 7.2% NaCI, sodium lactate and sodium acetate solutions along with oral electrolyte solution had an increase in venous blood pH, HCO 3 concentration, and base excess within 4 hours after the beginning of the administration. Increase in plasma volume and sodium concentration, but decrease in serum total protein were observed within 0.5 hours following administration of hypertonic 7.2% NaCI +oral electrolyte solution combination compared to other solution. The results of the study show that administration of IV hypertonic 7.2% NaCI solution in small volume along with oral electrolyte solution provided fast and effective improvement of dehydration and acid-base abnormalities within short time in treatment of calf diarrhea with mild -moderate dehydration and metabolic acidosis, compared to other treatment groups. This study aimed to describe the signalment, history, clinicopathologic and ultrasound findings, and outcome of adult cattle with histopathological diagnosis of cholangiohepatits. This is a report of 10 Holstein cows older than 12 weeks of age suffering from cholangiohepatitis. The diagnosis of cholangiohepatitis was based on the presence of a portal inflammatory infiltrate surrounding and/or infiltrating bile ducts, with or without epithelial damage, and extending into the adjacent lobules. Six cases were diagnosed with based on liver biopsy and four on post-mortem examination. Reasons for veterinary consultation were mostly decreased appetite and obtundation. The median age of the cows was 5 years (range: 3 months-7 years). At admission, five cows had complete anorexia and five had decreased appetite. The median rectal temperature was 38.9°C (37.7-40°C). Median heart rate was 98 bpm (78-120 bpm). Icterus was present in three cows. Four cows were mildly dehydrated (5-7%), three moderately (8-10%) and one severely (>10%). Four cows had absence or scant feces, one diarrhea with melena. Comorbidity included photosensibilization (n = 3), abomasal dilation/displacement (n = 2), salmonellosis (n = 2), peritonitis (n = 2), glomerulonephritis (n = 1) obstruction of the bile duct (n = 1). The most remarkable hematology findings include leucocytosis (>12.000 cells/lL) in six cases, marked neutophilia (>4.000 cells/ lL) in eight cases, four cows had toxic changes identified in the neutrophils and hyperfibrinogenemia (>500 mg/dL) was determined in seven cases. Alteration in the serum biochemistry profile included increased globulin levels (>4.9 mg/dL) in six cases, hypoalbuminemia (<3 g/dL) in six cases, elevated AST (>127 IU/L) in six cases, elevated GGT (>39 IU/L) in six cases, and increased total bilirubin (>75 lmol/L) was detected in four cows. Ultrasonographic examination of the liver and the gall bladder may reveal dilation of the extrahepatic and intrahepatic bile ducts, dilation of gallbladder and increased thickness of the wall. Two out six cows diagnosed by biopsy did not survive and 4 were discharged. The median time of hospitalization for the surviving cows was 9