2016 ACVIM Forum Research Abstract Program

In conclusion, the metabolome and microbiome vary along the canine GIT and further studies are needed to explore the effect of local disease at specific sites, to determine the host versus microbial origin of these metabolites, and possibly to enhance extrapolation from fecal assay results to improve our understanding of GI diseases. The abnormal interaction between the GI microbiome and the immune system is a major contributing factor to IBD. Treatment often includes the use of antimicrobials like metronidazole or the use of an elimination diet (i.e., hydrolyzed protein diet), but their effects on the intestinal microbiota are not well studied. Recent epidemiological studies in humans have linked gut dysbiosis due to antibiotics as risk factor for various chronic diseases, such as obesity, diabetes, and asthma. A better understanding of the functional effects of antibiotics and diets on the microbiome is needed. The aim of this study was to prospectively evaluate the impact of metronidazole administration versus hydrolyzed protein diet on the metabolome of healthy dogs.