Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_3
Snippet: As the study is ongoing no final conclusions can be made although synchronous VDD pacing appears to more closely approximate sinus rate and have slower atrial rates than asynchronous VVI or VVIR pacing. All dogs will have completed the study within the next two months at which time final conclusions can be made. Clopidogrel is considered mainstay therapy for the prevention of cardiogenic thromboemboli in cats and has been shown to be superior to .....
Document: As the study is ongoing no final conclusions can be made although synchronous VDD pacing appears to more closely approximate sinus rate and have slower atrial rates than asynchronous VVI or VVIR pacing. All dogs will have completed the study within the next two months at which time final conclusions can be made. Clopidogrel is considered mainstay therapy for the prevention of cardiogenic thromboemboli in cats and has been shown to be superior to aspirin. Clopidogrel is a pro-drug and requires hepatic bioactivation through cytochrome p450 for formation of the clopidogrel active metabolite (CAM), which is unstable and challenging to quantitate. After bioactivation, CAM binds to the ADPreceptor on platelets and inhibits platelet aggregation. Recently, a method to stabilize CAM in human plasma has been developed by adding 2-bromo-3'methoxyacetophenone (BMAP) to blood tubes. Once stabilized, the derivatized CAM (CAM-D) can be quantitated using high-performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS).
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