2016 ACVIM Forum Research Abstract Program

In the group N, median EF of the dogs treated with mosapride was significantly higher than those without the treatment [46.1% (range: 44.1 to 60.6) versus 38.1% (24.2 to 43.5%), respectively, P < 0.05]. Such tendency was also observed in the group S, although the difference was not significant [treatment: 43.3% (33.9 to 63.2%) versus without treatment: 34.8% (23.6 to 37.7%), P = 0.06]. However, the median degree of the increase of the plasma motilin concentrations after feeding was not significantly different between the dogs with and without mosapride in either group [Group N: mosaporide: À1.6 pg/mL (range: -123.3 to 168.3 pg/mL) versus feeding only: 65.0 pg/mL (-25.0 to 415.0 pg/ mL), Group S: mosaporide: 37.0 pg/mL (range: -273.0 to 95.0 pg/ mL) versus feeding only: 173.3 pg/mL (5.0 to 363.3 pg/mL)]. In Western blotting, an immunoreactive band was observed at the position of 45 kDa using the protein purified from the archived gallbladder, suggesting that 5-HT 4 is expressed in the canine gallbladder.