2016 ACVIM Forum Research Abstract Program

In a within subjects, pre to post design, 6 adult healthy colony cats received either omeprazole (0.83-1.6 mg/kg PO q12 h) or placebo (250 mg lactulose PO q12 h) for 60 days. Analyses of serum calcium, magnesium, cobalamin and gastrin concentrations were performed on days 0, 30, and 60, with dual energy x-ray absorptiometry performed at days 0 and 60 for each treatment. On day 60 of omeprazole treatment, intragastric pH capsules were placed in two of the cats to measure the effects of rapid omeprazole cessation. Continuous data were analysed using a two-way ANOVA and tested to account for the effects of phase of treatment, time of measurement and the interaction of phase and time. Log transformation of serum gastrin, bone mineral density (BMD) and bone mineral content (BMC) were required for the data to meet ANOVA normality assumptions. To reduce the possibility of a Type I error due to analysis of multiple study variables, the Bonferroni correction was applied (a = 0.006). SAS 9.4 was used to perform all data analyses and generate all descriptive statistics.