Author: Song, Jae-Hyoung; Shim, Aeri; Kim, Yeon-Jeong; Ahn, Jae-Hee; Kwon, Bo-Eun; Pham, Thuy Trang; Lee, Jongkook; Chang, Sun-Young; Ko, Hyun-Jeong
Title: Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection Document date: 2018_5_2
ID: 0bwf8f1i_38
Snippet: Next, we assessed the histological changes in lungs of HRV1B-infected mice. Lungs from uninfected mice exhibited typical normal pulmonary tissue, whereas rhinovirus-infected mice demonstrated characteristic inflammatory lesions with viral infection, including necrotizing bronchiolitis and interstitial pneumonia (Fig. 5A) . On the other hand, rhinovirus-infected Biomol Ther 26 (6) mice treated with pochonin D showed moderate inflammation with redu.....
Document: Next, we assessed the histological changes in lungs of HRV1B-infected mice. Lungs from uninfected mice exhibited typical normal pulmonary tissue, whereas rhinovirus-infected mice demonstrated characteristic inflammatory lesions with viral infection, including necrotizing bronchiolitis and interstitial pneumonia (Fig. 5A) . On the other hand, rhinovirus-infected Biomol Ther 26 (6) mice treated with pochonin D showed moderate inflammation with reduced necrosis, inflammatory cell infiltrates, and pulmonary edema compared to those in rhinovirus-infected mice without treatment. We scored the lung sections based on the extent of edema, hemorrhage, and cell infiltration (Fig. 5B ).
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