Author: Wu, Joseph T.; Peak, Corey M.; Leung, Gabriel M.; Lipsitch, Marc
Title: Fractional Dosing of Yellow Fever Vaccine to Extend Supply: A Modeling Study Document date: 2016_11_10
ID: 02pjdufw_24
Snippet: If vaccine action is "leaky," then the benefit threshold (the efficacy of n-fold fractionated doses necessary to reduce IAR) is higher than 1/n and increases with transmission intensity (Figure 3 ). This occurs because under the leaky model each infectious bite is assumed to be less likely to cause infection if the host is vaccinated, but the probability of infection grows as the person receives more infectious bites. Figure 3 shows, under the le.....
Document: If vaccine action is "leaky," then the benefit threshold (the efficacy of n-fold fractionated doses necessary to reduce IAR) is higher than 1/n and increases with transmission intensity (Figure 3 ). This occurs because under the leaky model each infectious bite is assumed to be less likely to cause infection if the host is vaccinated, but the probability of infection grows as the person receives more infectious bites. Figure 3 shows, under the leaky model of vaccine action, dose fractionation is much less beneficial if vaccine action is leaky, efficacy is modest, and R 0 is high. See appendix for the mathematical details.
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