Selected article for: "asthma lung function and lung function decline"
Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
  • Document date: 2019_6_4
    • ID: 6j3k3viu_14
    Snippet: IL13 is a major effector of T-helper cell type 2 (Th2) inflammation and has the potential to induce airway remodeling in asthma. 24 Previous studies have investigated the contribution of SNPs in IL13 to asthma outcomes including decline in lung function in asthma and the features of airway remodeling in asthma. In studies of Asian populations, the IL13 rs20541 AA allele was associated with lower FEV1 25 and a rapid decline of FEV1%. 26 It was als.....
    Document: IL13 is a major effector of T-helper cell type 2 (Th2) inflammation and has the potential to induce airway remodeling in asthma. 24 Previous studies have investigated the contribution of SNPs in IL13 to asthma outcomes including decline in lung function in asthma and the features of airway remodeling in asthma. In studies of Asian populations, the IL13 rs20541 AA allele was associated with lower FEV1 25 and a rapid decline of FEV1%. 26 It was also associated with increased subepithelial basement membrane thickness quantitated in endobronchial biopsy specimens obtained from 411 asthmatics. 27 Therefore, the IL13 rs20541 AA allele maybe associated with decline in lung function and selective features of airway remodeling such as subepithelial fibrosis due to basement membrane thickening.

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