Selected article for: "AIRWAY LUNG function and lung function decline"
Author: Hur, Gyu Young; Broide, David H.
Title: Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma
  • Document date: 2019_6_4
    • ID: 6j3k3viu_41
    Snippet: MMPs are involved in extracellular matrix turnover and tissue repair. Studies in asthma have particularly focused on the role of MMP-9 (gelatinase B) in airway remodeling, 56 as it plays a key role in extracellular matrix turnover. Additional support for MMP-9 playing a role in asthma are derived from studies demonstrating that in asthma, the levels of MMP-9 are elevated 57 in blood, sputum, BAL and exhaled breath condensates from patients with a.....
    Document: MMPs are involved in extracellular matrix turnover and tissue repair. Studies in asthma have particularly focused on the role of MMP-9 (gelatinase B) in airway remodeling, 56 as it plays a key role in extracellular matrix turnover. Additional support for MMP-9 playing a role in asthma are derived from studies demonstrating that in asthma, the levels of MMP-9 are elevated 57 in blood, sputum, BAL and exhaled breath condensates from patients with asthma exacerbations. MMP-9-deficient mice have slightly less peribronchial fibrosis and total lung collagen compared to wild type mice. 58 However, MMP-9 deficient mice still have mucus hypersecretion, smooth muscle thickness and AHR, suggesting that in mice many of the features of airway remodeling are not controlled by MMP-9. 58 At present, there are no studies of SNPs in MMP-9 and their effect on decline in lung function or airway remodeling in asthma.

    Search related documents:
    Co phrase search for related documents
    • additional support and key role: 1
    • airway lung function and asthma exacerbation: 1, 2, 3, 4
    • airway lung function and asthma role: 1, 2, 3
    • airway lung function and asthma role play: 1
    • airway lung function and asthma study: 1, 2, 3
    • airway lung function and BAL sputum: 1
    • airway lung function and breath condensate: 1
    • airway lung function and lung function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53
    • airway lung function and mucus hypersecretion: 1, 2
    • airway lung function and smooth muscle: 1, 2, 3, 4, 5
    • airway lung function and SNPs study: 1
    • airway lung function decline and asthma exacerbation: 1
    • airway lung function decline and lung function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
    • airway lung function decline and smooth muscle: 1, 2, 3, 4