Selected article for: "codon position and GC content"
Author: Pope, Welkin H.; Jacobs-Sera, Deborah; Russell, Daniel A.; Rubin, Daniel H. F.; Kajee, Afsana; Msibi, Zama N. P.; Larsen, Michelle H.; Jacobs, William R.; Lawrence, Jeffrey G.; Hendrix, Roger W.; Hatfull, Graham F.
Title: Genomics and Proteomics of Mycobacteriophage Patience, an Accidental Tourist in the Mycobacterium Neighborhood
  • Document date: 2014_12_2
    • ID: 7m53i1h9_16
    Snippet: Codon selection and adaptation for mycobacterial growth. Because M. smegmatis has a relatively high GC content (67.4%), it is not surprising that these mutational biases (reflected in base composition) result in frequent usage of GC base pairs in thirdcodon positions (Fig. 6A ; see also Fig. S3 and S4 in the supplemental material). Each of the most commonly used of the synonymous codons has GC in the third position, and M. smegmatis mc 2 155 carr.....
    Document: Codon selection and adaptation for mycobacterial growth. Because M. smegmatis has a relatively high GC content (67.4%), it is not surprising that these mutational biases (reflected in base composition) result in frequent usage of GC base pairs in thirdcodon positions (Fig. 6A ; see also Fig. S3 and S4 in the supplemental material). Each of the most commonly used of the synonymous codons has GC in the third position, and M. smegmatis mc 2 155 carries tRNAs with anticodons corresponding to all codons with GC in the third position, except for CGC (Fig. S3) . All of the NNU codons are present infrequently and (with the exception of CGU) are decoded by wobble pairing in the codon third position (Fig. S3 and S4) ; M. tuberculosis H37Rv has an almost identical tRNA profile.

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