Selected article for: "candidate probe and cover extension term"
Author: Hayden C. Metsky; Katherine J. Siddle; Adrianne Gladden-Young; James Qu; David K. Yang; Patrick Brehio; Andrew Goldfarb; Anne Piantadosi; Shirlee Wohl; Amber Carter; Aaron E. Lin; Kayla G. Barnes; Damien C. Tully; Björn Corleis; Scott Hennigan; Giselle Barbosa-Lima; Yasmine R. Vieira; Lauren M. Paul; Amanda L. Tan; Kimberly F. Garcia; Leda A. Parham; Ikponmwonsa Odia; Philomena Eromon; Onikepe A. Folarin; Augustine Goba; Etienne Simon-Lorière; Lisa Hensley; Angel Balmaseda; Eva Harris; Douglas Kwon; Todd M. Allen; Jonathan A. Runstadler; Sandra Smole; Fernando A. Bozza; Thiago M. L. Souza; Sharon Isern; Scott F. Michael; Ivette Lorenzana; Lee Gehrke; Irene Bosch; Gregory Ebel; Donald Grant; Christian Happi; Daniel J. Park; Andreas Gnirke; Pardis C. Sabeti; Christian B. Matranga
Title: Capturing diverse microbial sequence with comprehensive and scalable probe design
  • Document date: 2018_3_12
    • ID: a9lkhayg_43
    Snippet: CATCH then maps each candidate probe p back to the target sequences with a seed-andextend-like approach, in the process deciding whether p maps to a range r in a target sequence according to a function f map (p, r, θ d ). f map effectively specifies whether p will capture the subsequence at r. Further, CATCH assumes that because p captures an entire fragment and not just the subsequence to which it binds, p "covers" both r and some number of bas.....
    Document: CATCH then maps each candidate probe p back to the target sequences with a seed-andextend-like approach, in the process deciding whether p maps to a range r in a target sequence according to a function f map (p, r, θ d ). f map effectively specifies whether p will capture the subsequence at r. Further, CATCH assumes that because p captures an entire fragment and not just the subsequence to which it binds, p "covers" both r and some number of bases (given in θ d ) on each side of r; we term this a "cover extension". This yields a collection of bases in the target sequences that are covered by each p, namely:

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