Author: Warnes, Sarah L.; Little, Zoë R.; Keevil, C. William
Title: Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials Document date: 2015_11_10
ID: 4d4l6mzl_17
Snippet: A combination of genetic reassortment in viruses with segmented genomes and point mutations, particularly evident in viruses that cause disease in the respiratory tract such as influenza virus and coronaviruses, results in constantly changing antigenicity and host immune response evasion. This can also affect the attachment to the host cell receptor and the "host jump" from animals to human that can occur if the mutation results in an increased a.....
Document: A combination of genetic reassortment in viruses with segmented genomes and point mutations, particularly evident in viruses that cause disease in the respiratory tract such as influenza virus and coronaviruses, results in constantly changing antigenicity and host immune response evasion. This can also affect the attachment to the host cell receptor and the "host jump" from animals to human that can occur if the mutation results in an increased ability of the virus to bind to human cells. If this is accompanied by a decrease in binding to the original host, then human-to-human transmission can occur, presenting a substantial threat of rapid spread of a novel virus throughout the community (reviewed in reference 32).
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