Author: Hayden C. Metsky; Katherine J. Siddle; Adrianne Gladden-Young; James Qu; David K. Yang; Patrick Brehio; Andrew Goldfarb; Anne Piantadosi; Shirlee Wohl; Amber Carter; Aaron E. Lin; Kayla G. Barnes; Damien C. Tully; Björn Corleis; Scott Hennigan; Giselle Barbosa-Lima; Yasmine R. Vieira; Lauren M. Paul; Amanda L. Tan; Kimberly F. Garcia; Leda A. Parham; Ikponmwonsa Odia; Philomena Eromon; Onikepe A. Folarin; Augustine Goba; Etienne Simon-Lorière; Lisa Hensley; Angel Balmaseda; Eva Harris; Douglas Kwon; Todd M. Allen; Jonathan A. Runstadler; Sandra Smole; Fernando A. Bozza; Thiago M. L. Souza; Sharon Isern; Scott F. Michael; Ivette Lorenzana; Lee Gehrke; Irene Bosch; Gregory Ebel; Donald Grant; Christian Happi; Daniel J. Park; Andreas Gnirke; Pardis C. Sabeti; Christian B. Matranga
Title: Capturing diverse microbial sequence with comprehensive and scalable probe design Document date: 2018_3_12
ID: a9lkhayg_71
Snippet: In the plots showing probe counts as a function of parameter values ( Supplementary Fig. 1c) , we varied only the mismatches (m) and cover extension (e) parameters using the values shown. We set parameters on the longest common substring (lcf ) and island of exact match (i) to their default values: lcf equal to the probe length (75) and i = 0. For each pair of parameter values shown, we calculated probe counts across 5 replicates, with the input.....
Document: In the plots showing probe counts as a function of parameter values ( Supplementary Fig. 1c) , we varied only the mismatches (m) and cover extension (e) parameters using the values shown. We set parameters on the longest common substring (lcf ) and island of exact match (i) to their default values: lcf equal to the probe length (75) and i = 0. For each pair of parameter values shown, we calculated probe counts across 5 replicates, with the input to each replicate being 300 genomes that were randomly selected with replacement. Shaded regions are 95% pointwise confidence bands.
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