Author: Yen, Wei-Chen; Wu, Yi-Hsuan; Wu, Chih-Ching; Lin, Hsin-Ru; Stern, Arnold; Chen, Shih-Hsiang; Shu, Jwu-Ching; Tsun-Yee Chiu, Daniel
Title: Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling Document date: 2019_11_2
ID: 6fw4thkq_41
Snippet: G6PD knockdown reduced the expression of mature IL-1β, but not the expression of caspase-1 or the components of the inflammasome (NLRP3, ASC and pro-Caspase-1) (Fig. 3A) . A decrease in the translational level of pro-IL-1β upon inflammasome activation was detected by a Western blot (Fig. 3B) in G6PD-kd THP-1 cells compared to the level in the controls. The quantitative intensity of pro-IL-1β is shown in Fig. 3C . The mRNA level of IL-1β also .....
Document: G6PD knockdown reduced the expression of mature IL-1β, but not the expression of caspase-1 or the components of the inflammasome (NLRP3, ASC and pro-Caspase-1) (Fig. 3A) . A decrease in the translational level of pro-IL-1β upon inflammasome activation was detected by a Western blot (Fig. 3B) in G6PD-kd THP-1 cells compared to the level in the controls. The quantitative intensity of pro-IL-1β is shown in Fig. 3C . The mRNA level of IL-1β also decreased in G6PD-kd THP-1 cells (Fig. 3D ).
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