2016 ACVIM Forum Research Abstract Program

These results failed to show an association between relapse of presumptive primary ITP in dogs and vaccination, although the possibility cannot be excluded. Future studies assessing higher numbers of dogs would be required to further assess a potential association. Aspirin, or acetylsalicylic acid (ASA), is a cyclooxygenase inhibitor that prevents the synthesis of hemostatically active prostaglandins. At low doses aspirin is used to inhibit platelet function and ultimately thrombus formation. Some human patients appear non-responsive to these antiplatelet effects, termed "aspirin resistance." This same phenomenon has been identified in dogs and could be a contributing factor to the formation of thromboemboli in some at risk patients. Accurately predicting aspirin response prior to treatment could prevent inappropriate drug therapy and devastating thrombus formation in otherwise manageable diseases.